For a much more detailed guide, please have a look at our myxofibrosarcoma information pack.


Also known as:

  • Myxoid malignant fibrous histiocytoma (old name – no longer used)
  • Myxoid MFH: (old name – no longer used)
  • Myxofibroblastic sarcoma:
  • MFS

What is myxofibrosarcoma?

Often seen as a painless, slow growing lump, MFS tumours tend to form in the connective tissues of the arms and legs close to the surface although they may be found deeper into the tissue. The name reflects a mixture of myxoid, or mucous containing cells and cells that look like fibrous connective tissue. They have many different genetic mutations which means tumour sequencing techniques are less useful in making a firm diagnosis. 

MFS can return aggressively after surgery, so surgery often takes a wide margin of tissue and is combined with radiotherapy.

How rare is myxofibrosarcoma?

Myxofibrosarcoma is one of the more common sarcomas, affecting 2-3 people per 100,000 each year.

Who does myxofibrosarcoma affect?

Myxofibrosarcoma usually affects older people, typically over 60, but cases are occasionally seen in younger people. There are slightly more cases in men, than in women.

Why is RareCan interested in myxofibrosarcoma?

RareCan is working to accelerate research into myxofibrosarcoma by making it easier for researchers to connect with people who have it. You can help us do this by becoming a RareCan member and sharing information with us about your myxofibrosarcoma diagnosis. We will then get in touch with you about any research opportunities that might be suitable for you.

Looking for a different cancer type?

Please visit our ‘rare cancer list’ to search for your cancer type¬†

Useful links

If you are looking for further support with myxofibrosarcoma we recommend the following websites:

Sarcoma UK

Sarcoma UK

Sarcoma UK is a charity for those with bone and soft tissue sarcoma diagnoses. They provide information on all types of sarcomas and have a patient support line to help assist with any queries and worries.