Also Known As:
- Overt Primary Myelofibrosis
- Overt PMF
Why is RareCan interested in Myelofibrosis?
RareCan is working to accelerate research into Primary Myelofibrosis by making it easier for researchers to connect with people who have this rare form of blood cancer. You can help us do this by becoming a RareCan member and sharing information with us about your PMF diagnosis. We will then get in touch with you about any research opportunities that might be suitable for you.
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What is Primary Myelofibrosis?
Primary Myelofibrosis is a rare blood cancer that occurs in the bone marrow. It is often associated with mutations in the JAK2, CALR, or MPL gene markers, although around 10% of people with PMF do not carry any of these mutations.
How rare is Myelofibrosis?
Myelofibrosis occurs in around 1 per 100,000 people per year.
Who does Myelofibrosis affect?
Primary Myelofibrosis mainly affects people over the age of 50 but it can happen at any age. 90% of people with PMF carry somatic mutations in the JAK2, CALR, or MPL gene markers, but 10% do not.
Related Cancer Types
- PMF is classified as a type of Myeloproliferative Neoplasm, a group of cancers that affect the bone marrow.
- Prefibrotic Primary Myelofibrosis
- Polycythemia Vera
- Essential Thrombocythaemia
If you have Myelofibrosis/Primary Myelofibrosis/Overt Primary Myelofibrosis and are looking for support, we recommend the following websites:
Blood Cancer UK is a community dedicated to funding research and support for those affected by blood cancers like Myelofibrosis.
Opportunities for Members with Primary Myelofibrosis
The RareCan BioResource
Donating your samples for medical research
Joining RareCan gives you the ability to donate your tissue samples to the BioResource for medical research. Please note that signing up to RareCan does not commit you to donating tissue and you can cancel your membership at any time. If you have Myelofibrosis and would like to find out more, please click the button below.
I have a cancer diagnosis
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I'm a supporter
If you’re a friend or family member of someone with cancer, a nurse, an oncologist, an activist, a fundraiser or you’d simply like to help, please start here.
I'm a researcher
If you are interested in setting up a research project or clinical trial aimed at improving the care people affected by rare cancer receive please start here.